Physical Education
Mehdi Zarei; Rahim Golmohammadi; Elham Iziy; Seyed Mehdi Beheshti Nasr
Volume 28, Issue 2 , May and June 2021, , Pages 165-172
Abstract
Introduction: There has been no report on the effect of epilepsy on liver enzymes and lipoproteins and its changes following exercisetraining in epileptic rats with Pentylenetetrazole. Materials and Methods: In this experimental study, 70 male rats were placed in 7 groups. An intact group, three groups ...
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Introduction: There has been no report on the effect of epilepsy on liver enzymes and lipoproteins and its changes following exercisetraining in epileptic rats with Pentylenetetrazole. Materials and Methods: In this experimental study, 70 male rats were placed in 7 groups. An intact group, three groups of Kindle and three groups of non-Kindle who received PTZ or normal saline injections every 48 hours until the animals were kindled. 24 hours after Kindling, blood samples were collected in intact group and two groups of Kindle and non-Kindle. One Kindle group and one non-Kindle group from the remaining four groups performed aerobic exercise for six weeks, and the other two groups were inactive for six weeks. Blood were collected 24 hours after the 6-week period, and were compared with control groups. Results: After 4 weeks of Kindling period, total cholesterol, triglycerides, low-density lipoprotein, liver enzymes (P <0.001) and antigenic coefficient (P <0.01) increased significantly in the epileptic group. After six weeks of aerobic exercise in Kindle animals; Triglycerides (P <0.001), liver enzymes (P <0.01) and antigenic coefficients significantly reduced, and high-density lipoprotein significantly increased (P <0.01). Conclusion: The results showed that aerobic exercise in epileptic rats with Pentylenetetrazole improved lipid profile impairement and increased liver enzymes caused by epilepsy.
Seyed Mehdi Beheshti Nasr; Mohammad Mohammadzadeh; Hasan Ramshini
Volume 21, Issue 2 , May and June 2014, , Pages 352-361
Abstract
Introduction: Minocycline has anticonvulsant effects. Since some antiepileptic drugs increase the neurotransmitter GABA in the brain, the aim of this study is the effect of minocycline on gene expression of GABAA receptor in hippocampus and piriform brain areas on amygdale kindling acquisition in rat.
Methods: ...
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Introduction: Minocycline has anticonvulsant effects. Since some antiepileptic drugs increase the neurotransmitter GABA in the brain, the aim of this study is the effect of minocycline on gene expression of GABAA receptor in hippocampus and piriform brain areas on amygdale kindling acquisition in rat.
Methods: In this experimental study, three group (24 Wistar rats), after stereotaxic surgery and 1 week recovery period, received kindling stimulations(twice daily at 6 hours interval). Group 1(n=8) did not receive daily kindling stimulations. Group 2 (n=8) received intraperitoneal saline (1ml/kg) and Group 3 (n=8) received intraperitoeneal minocycline (25 mg/kg) 60 min before kindling stimulation and respectively. Two hours after the last stimulation, animals’ brains were removed and the changes of gene expression by γ2 subunit of GABAAreceptor in the hippocampus and piriform cortex were measured and compared with the control group. Data was analyzed using one-way ANOVA and Tukey post hoc tests (P
Ahamad Majid; Seyyed Mehdi Beheshti Nasr; Elham Izi; Mohammad Mohammadzadeh
Volume 20, Issue 2 , May and June 2013, , Pages 176-183
Abstract
Background: Cytisus scoparius is an ornamental and highly aromatic plant. The petals and stamens in aromatic plants are important allergenic agents. The aim of this study is examination study of allergenicity of petal and stamen in middle-aged ontogenical stage of Cytisus scoparius L. in guinea pig. ...
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Background: Cytisus scoparius is an ornamental and highly aromatic plant. The petals and stamens in aromatic plants are important allergenic agents. The aim of this study is examination study of allergenicity of petal and stamen in middle-aged ontogenical stage of Cytisus scoparius L. in guinea pig.
Methology: In this experimental study, 9 guinea pigs from hartly stirps were randomly selected and divided into three equal groups. Plant extracts were prepared with 16% concentration and injected intraperitoneally to guinea pigs.The first group was considered as negative control (injected with phosphate buffered saline). The second and the third groups received petal extract and petal + stamen extract respectively. In addition intraperitoneal injections within 4 weeks, once per week, subcutaneous injection was performed in the fifth week. Finally, a week after the last injection was taken blood sampling directly from the heart of animals, and the number of eosinophils, immunoglobulin E and blood sugar levels were measured in experimental groups and analyzed data.
Results: Skin test (Created wheal diameter) and serological tests (levels of immunoglobulin E, eosinophils, and blood glucose) in both groups treated with Cytisus scoparius L. significantly increased compared to controls. Electrophoretic profiles was observed about 4 protein bands (2 light protein bands and 2 pale protein bands) in the range of 27 to 85 kD in the middle-aged petal and about 6 more specific protein bands in the range of 10 to 75 kD in middle-aged petal whit stamen proteins.
Conclusion: The results showed that petal of ontogenical stage of middle-aged in Cytisus scoparius have allergenicity property and and this effect is exacerbated when they are together with stamens.
Ali Moghimi; Mohammad Mohammad-Zadeh; Seyyed Mehdi Beheshti Nasr
Volume 19, Issue 1 , March and April 2012, , Pages 14-25
Abstract
Background: Minocycline is an antibiotic and anti-inflammatory drug. In addition, its neuroprotective effects have been shown. Since there is interaction between cell death and seizure, the aim of this study is examination of the role of minocycline on amygdala-kindled seizures in rat.
Materials and ...
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Background: Minocycline is an antibiotic and anti-inflammatory drug. In addition, its neuroprotective effects have been shown. Since there is interaction between cell death and seizure, the aim of this study is examination of the role of minocycline on amygdala-kindled seizures in rat.
Materials and Methods: In this experimental study, three groups of animals (18 rats), after stereotaxic surgery and 1-week recovery period, received twice daily kindling stimulations. In fully kindled animals of groups 1-3, minocycline was injected intraperitoneally in doses 12.5 (n = 7), 25 (n = 5) and 50 (n = 6) mg/kg, respectively, 60 minutes before stimulation. Afterdischarge duration (ADD), stage 4 latency (S4L), Stage 5 Duration (S5D) and Seizure Duration (SD) were recorded and compared with related control groups (the same animals that had received saline 1 day before). A p-value of less than 0.05 was considered to represent a significant difference.
Results: In fully kindled animals who had received minocycline (50 and 25 mg/kg), ADD decreased significantly. When minocycline was delivered, S5D decreased 38.3% (p < 0.001), 34% (p